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Title: Biochemical screening for fetal chromosome abnormalities
Author: Crossley, Jennifer A.
Awarding Body: University of Glasgow
Current Institution: University of Glasgow
Date of Award: 1993
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The aim of this project was to explore ways of using biochemical screening to improve the prenatal detection rate for Down's syndrome and other chromosome abnormalities over that being achieved using maternal age alone. It is well established that the risk of a pregnancy being affected by Down's syndrome or one of the other autosomal trisomies increases with advancing maternal age, and since the early 1970s this has been the criterion used to select women for diagnostic fetal chromosome analysis. However, the majority of affected pregnancies (70%) are born to women under 35 years of age and the uptake of diagnostic testing amongst women aged 35 years and over has been relatively low (< 40%) leading to only around 12% of the affected pregnancies being detected in practice.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available