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Title: Structural studies on the Herpes Simplex Virus Type 1 genome during latency in tissue culture cells
Author: Jamieson, Douglas Ramsay Stuart
Awarding Body: University of Glasgow
Current Institution: University of Glasgow
Date of Award: 1993
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Herpes simplex virus (HSV) has the pathogenic property of establishing latency during primary infection of man. Following the primary infection at a peripheral site, virions travel via the axons to the neuronal cell bodies in sensory or autonomic ganglia where latency is established and maintained. The virus can be reactivated, return down the axon to the periphery, replicate, be shed and transmitted to other individuals. This gives rise to clinically important recurrent disease, namely herpes labialis, keratitis, uveitis and genitalis. Reactivation is of increasing importance in immunocompromised individuals. Encephalitis, presumed to be due to reactivation of latent virus from the trigeminal ganglion, is the most serious manifestation with a mortality rate of about 50% if untreated and considerable morbidity in half of the survivors.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available