Use this URL to cite or link to this record in EThOS: https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.788501
Title: Actions of oxygen-derived free radicals and reactive oxygen species on the organelles of force production and calcium storage in cardiac muscle
Author: MacFarlane, Niall Gordon
Awarding Body: University of Glasgow
Current Institution: University of Glasgow
Date of Award: 1993
Availability of Full Text:
Access from EThOS:
Access from Institution:
Abstract:
The work which comprises this thesis concerns the effects of oxygen-derived free radicals and reactive oxygen species on the intracellular organelles of force production and calcium storage in cardiac muscle. In addition, the possibility of endogenous histidine-containing compounds having antioxidant activity has been investigated. Preparations treated with Triton-X100 retain only traces of membrane structure while the contractile proteins remain functional. This form of treatment is ideal for investigating alterations to myofilament calcium sensitivity and maximum calcium-activated force production. Saponin-treated trabeculae retain the intracellular membranes associated with the sarcoplasmic reticulum and the mitochondria, while the sarcolemma is rendered permeable to the experimental solutions. This form of treatment is ideal for investigating alterations to sarcoplasmic reticulum and mitochondrial function.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID: uk.bl.ethos.788501  DOI: Not available
Share: