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Title: Synthesis of novel biological nanostructures
Author: Abdelhamid, Mahmoud
ISNI:       0000 0004 7973 2350
Awarding Body: University of East Anglia
Current Institution: University of East Anglia
Date of Award: 2019
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Chapter 1 is a general introduction to the field surrounding quadruplex DNA with a focus on the i-motif, a quadruplex DNA structure. Chapter 2 is split into three sections and explores the interactions of cations with quadruplex DNA. The first section discusses what was already known about the effects of cations on the G-quadruplex and i-motif structures. The second section describes the effects observed upon addition of a range of cations to the i-motif. The final section describes the discovery and characterisation of a redoxdependent system for the control of i-motif DNA structure using copper cations. Chapter 3 explores the interaction of small molecules with quadruplex DNA. The first section discusses reports in the literature relating to the effects of ligands on the G-quadruplex and the i-motif. The second describes our efforts using a variety of screening methodologies to identify a ligand that is specific for i-motif. The third describes how 'specific' G-quadruplex ligands have been found to interact with the i-motif. Chapter 4 begins with an introduction on the use of DNA as a functional material. This is followed by a discussion of DNA tetrahedra and introduces the proposed design of a novel biological nanostructure in an attempt to exploit quadruplex DNA to impart further functionality to DNA nanoarchitectures. The third section discusses the efforts in synthesising the structure. Chapter 5 offers a general discussion about this body of work and explores avenues for the future development of it. Chapter 6 describes the experimental procedures used in Chapters 2, 3 and 4.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available