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Title: Tool development for metabolic analyses in the context of thermodynamic constraints
Author: Martinez Vernon, Andrea S.
ISNI:       0000 0004 7972 4254
Awarding Body: University of Warwick
Current Institution: University of Warwick
Date of Award: 2018
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Metabolism is key to all biological processes. Studies have yet to establish the link between metabolism, extracellular electron transfer and thermodynamics. In this context, I successfully developed a platform to enable electrochemical experiments using strict anaerobic microorganisms to quantify the electron transfer in an effort to measure metabolic rates. This involved establishing a novel hypothesis to investigate "syntrophy over wires". Moreover, I developed a computational tool, MetQy, to enable the automated, large-scale analysis of annotated genomes with metabolic information in the form of an R package. The work I presented here has paved the way for electrochemical and computational analyses towards characterising and better understanding metabolic-electronic interactions in the context of thermodynamics.
Supervisor: Not available Sponsor: Engineering and Physical Sciences Research Council ; Biotechnology and Biological Sciences Research Council
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available
Keywords: QP Physiology