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Title: The contribution of the cytotoxic effector molecule granulysin released by Vδ2+ γδ T cells, to the migration and maturation of dendritic cells
Author: Sparrow, Emma Louise
ISNI:       0000 0004 7972 1803
Awarding Body: St George's, University of London
Current Institution: St George's, University of London
Date of Award: 2018
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BACKGROUND: Vδ2+ γδ T cells can kill tumour directly or indirectly through activation of immune effectors. The link between innate and adaptive immune responses to tumour is partly attributed to granulysin secretion by Vδ2+ γδ T cells. A cytolytic 9 kDa isoform of granulysin kills tumour directly, while a 15 kDa precursor is thought to be a chemoattractant for other immune cells, particularly dendritic cells. Attraction of dendritic cells to tumour would allow initiation of adaptive immune responses, through their internalization of tumour material and migration to lymph nodes, activating CD4+ and CD8+alpha beta T cells.
Supervisor: Bodman-Smith, M. ; Dalgleish, A. ; Fowler, D. W. Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available