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Title: Carbon nanotubes for the rapid detection of intracellular hydrogen peroxide and its application in bacterial detection
Author: Hicks, Jacqueline
Awarding Body: University of Nottingham
Current Institution: University of Nottingham
Date of Award: 2019
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The aim of this work is to develop a biosensor capable of detecting bacteria through the specific detection of intracellular hydrogen peroxide. When bacteria interact with host phagocytic immune cells there is a burst of reactive oxygen species known as the respiratory burst. Traditionally this is thought to be a long and extended production of reactive oxygen species. Recent advances however, have shown that the respiratory burst can be more dynamic with a fast and rapid response to bacteria. Conventional techniques for the measurement of reactive oxygen species are limitedin their ability to differentiate between reactive oxygen species and to detect them in a time sensitive manner. In order to fulfil this need for a rapid sensor, an electrochemical nano-biosensor was developed that can interface with cells interacting with the cell cytoplasm and detect hydrogen peroxide in a time and concentration dependent manner. Such a development is a vital first step in the production of a rapid diagnostic device that will aid physicians in correctly treating bacterial infection and will be of particular use in the treatment of sepsis.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available
Keywords: R855 Medical technology. Biomedical engineering. Electronics