Use this URL to cite or link to this record in EThOS: https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.785594
Title: Synthetic vesicles from stimuli-responsive amphiphiles
Author: Li, Wen
Awarding Body: University of Manchester
Current Institution: University of Manchester
Date of Award: 2017
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Abstract:
The design of stimuli-responsive vesicles that become permeable, disassemble, or change shape in response to an external trigger or oscillating signal is a promising strategy in the development of drug delivery systems and soft materials, and may assist in the understanding of artificial cells and synthetic tissue. A cationic quaternary surfactant DDAB-CHO 19 has been synthesized that is structurally analogous to didodecyldimethylammonium bromide 1 (DDAB), but bears an aldehyde at the terminus of one lipid chain. Initially assemblies at thermodynamic equilibrium were created from this lipid. The addition of amines to suspensions of this aldehyde surfactant gave exchangeable 'iminolipids' that self-assembled into vesicles in water. Any surfactant library obtained might make it possible to encourage interactions with specific materials and surfaces, providing a cationic hydrophilic coating surface. Then two approaches to forming assemblies under non-equilibrium conditions were explored. To create light-sensitive amphiphiles, a traceless method of removing hydrophilic solubilizing groups photochemically using diazene chemistry was explored. After uncaging this could give unfunctionalised hydrophobic alkyl groups that drive self-assembly in water. Furthermore the sulfite responsiveness of aldehydic amphiphiles was explored. Aldehydic amphiphiles were reacted with bisulfite-sulfite buffer to give a clock reaction. In combination with continuously stirred tank reactor (CSTR) this could generate an aldehyde-sulfite oscillating system which could produce pulses of self-assembled structures (e.g., vesicles).
Supervisor: Pritchard, Robin ; Webb, Simon Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID: uk.bl.ethos.785594  DOI: Not available
Keywords: Synthetic Vesicles ; Surfactants ; Dynamic amphiphiles ; Graphene ; Photochemistry ; DCC
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