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Title: Microglia : cell therapy for Alzheimer's disease
Author: Marques, Luis M. Costa
ISNI:       0000 0004 7970 8991
Awarding Body: Loughborough University
Current Institution: Loughborough University
Date of Award: 2019
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Alzheimer's disease (AD) is the most common type of dementia (>70% of the cases). Although it was discovered more than one century ago, the existing treatments for AD only produce a modest amelioration of the symptoms and there is still no available cure. AD not only causes severe distress to the patients and caregivers, but it is also associated with a large economic burden to society, since after the age of 65, the risk of developing AD doubles every five years, and by the age 85 the prevalence increases to 50%. This large and global impact is inherently associated with current major challenges in AD, which include the lack of effective treatments, preventive strategies and reliable biomarkers for early diagnosis.
Supervisor: Not available Sponsor: EPSRC ; MRC
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available
Keywords: Mechanical Engineering not elsewhere classified ; Alzheimer's disease ; Microglia ; Cell therapy ; Inflammation ; Senescence