Use this URL to cite or link to this record in EThOS: https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.785376
Title: An investigation of the inflammatory resolution properties of Resolvin E1 in skeletal muscle cells
Author: Baker, Luke A.
ISNI:       0000 0004 7970 8959
Awarding Body: Loughborough University
Current Institution: Loughborough University
Date of Award: 2019
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Abstract:
A variety of metabolic disease states as well as the ageing process are characterised with a state of low-gradechronic inflammation, which may contribute to skeletal muscle wasting. Since muscle wasting is associated with increases in morbidity and all-cause mortality, targeting of skeletal muscle inflammation may prove a useful therapeutic tool to enable the preservation of skeletal muscle mass in disease states categorised by chronic low-grade inflammation. One potential avenue for intervention is via nutritional intervention, omega-3fatty acids have been implicated to have anti-inflammatory properties mediated via a variety of mechanisms. One such mechanism is through a group of bioactive lipid mediators produced in inflammatory states via the metabolism of both eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), which aretermed specialised pro-resolving mediators (SPM's).
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID: uk.bl.ethos.785376  DOI: Not available
Keywords: Medical and Health Sciences not elsewhere classified ; Skeletal muscle ; Atrophy ; Inflammation ; Resolvin E1 ; Resolution physiology
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