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Title: Multimodality characterization of tissue microstructure with Magnetic Resonance and Optical Spectroscopy
Author: Proverbio, A.
ISNI:       0000 0004 7970 5985
Awarding Body: UCL (University College London)
Current Institution: University College London (University of London)
Date of Award: 2016
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Cancer introduces changes in the microstructure of tissues, and different modalities can characterise specific features. Diffusion Magnetic Resonance investigates the diffusion of water molecules within the microstructure, providing contrast to describe the confinement of water in the different cytological compartments. The migration of photons and their polarisation status in a medium is conditioned by scattering and absorption where scattering is related to the micro and nanostructure. For the first time, we demonstrate the use of two modalities to inform a combined model describing microstructural features non-invasively. Diffusion MR and Optical Spectroscopy provide complementary information about the tissue, and a common model can be used to provide bio-markers indicating presence and staging a cancerous lesion. Here, the common model is fitted to the signals from each modality to inform a collective characterisation of the microstructure. A proof of concept on a sample (oil in water emulsion) is proposed to test the approach, where time-domain optical spectra have been combined with diffusion NMR echoes. To demonstrate the first steps towards clinical feasibility, a diffusion MR imaging, based on Oscillating Gradient Spin Echoes (OGSE), has been implemented to investigate the smallest elements of the microstructure of fixed samples obtained from two human colorectal cell lines. Diffusion OGSE MR imaging was then combined with polarised light spectroscopy. The ultimate aim is to provide an implementable method for clinical practice, where the optical modality can be acquired in gastroscopy, independently from the MRI imaging. The target is to diagnose colorectal cancer and stage the grade non-invasively. Furthermore, this work provides a method that can be extended to other modalities with minor changes.
Supervisor: Gibson, A. P. ; Alexander, D. C. Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available