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Title: Optimising antibody dependent killing of neuroblastoma
Author: Fisher, J. P.
ISNI:       0000 0004 7970 5811
Awarding Body: UCL (University College London)
Current Institution: University College London (University of London)
Date of Award: 2015
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Human γδT lymphocytes have potent anti-tumour efficacy in vitro and have some clinical efficacy against solid and haematological cancers. γδT cells of Vδ1+, Vδ2+ or Vδ1-/Vδ2- subsets expanded and purified from the blood of healthy donors or childhood cancer patients have distinct memory and activation phenotypes, and anti- tumour functions. Second generation chimeric antigen receptors (CARs) can enhance γδT cell anti-tumour efficacy but lead to on-target off-tumour toxicity. First generation co-stimulatory CARs also enhance anti-tumour cytotoxicity of γδT cells but avoid on-target off-tumour toxicity, suggesting a possible clinical approach to targeting a wide range of tumour associated antigens.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available