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Title: Mycobacterium tuberculosis glycolipids and their effects on HIV-1 infection and replication
Author: Pouget, Marion
ISNI:       0000 0004 7970 3875
Awarding Body: University of Liverpool
Current Institution: University of Liverpool
Date of Award: 2018
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Human Immunodeficiency Virus type 1 (HIV-1) and Mycobacterium tuberculosis (Mtb) co-infection results in a rapid loss of numerous immunological functions and ultimately leads to death when not treated. The WHO estimated in 2015 that 13 million people were infected by both pathogens, with 390,000 deaths related to tuberculosis among HIV-infected individuals. Mtb and HIV-1 can induce profound changes in the host immune response resulting in Mtb infections causing active disease or the exacerbation of HIV-1 infection. For aiding in the development of new treatments a better understanding of the interactions between both pathogens and the host is crucial. This thesis follows this perspective by aiming to characterise the impact Mtb glycolipids have on modulating HIV-1 infection and to identify Mtb strains that differentially modulate HIV-1 infection and immune cell innate signalling.
Supervisor: Paxton, William ; Pollakis, Georgios Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral