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Title: Influence of retinal cell density on structural and functional properties of the visual topographic map in mammals
Author: Perry, Ankur Shujon Wahhab
ISNI:       0000 0004 7970 0025
Awarding Body: King's College London
Current Institution: King's College London (University of London)
Date of Award: 2019
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Pax6-αCre+Dicerfl/fl transgenic mice contain retinal progenitor cells that undergo cell death in nasal and temporal retina during development, while maintaining a subset of wildtype, healthy retinal cells in the centre. I measured cell densities across the Pax6-αCre+Dicerfl/fl retina after the cells had dispersed to cover the nasotemporal gaps. I found that photoreceptors have a 30% reduction in cell density, while bipolar cell density is reduced by 37%, starburst amacrine cell density by 59% and retinal ganglion cells by 40%. This reduced retinal cell density has an effect on collicular representations of the visual scene. Electrophysiological recordings of collicular responses to visual stimuli were performed in control and Pax6-αCre+Dicerfl/fl animals. Receptive field sizes were larger and more scattered in their SC topographic representation in the state of reduced retinal cell density. No obvious alterations were found in SC orientation or direction selectivity. Hence reduced retinal cell density alters the magnification of visual space and functionally reduces topographic mapping precision while maintaining sensitivity to motion in the visual field. My findings suggest that the regulation of retinal cell density is important for forming a structurally precise and functionally accurate collicular map of visual space.
Supervisor: Hindges, Robert Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available