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Title: The role of autophagy in regulating Tumour Necrosis Factor Receptor-mediated biological responses in normal and malignant epithelial cells
Author: Nasef, Mohamed M.
ISNI:       0000 0004 7969 7508
Awarding Body: University of Huddersfield
Current Institution: University of Huddersfield
Date of Award: 2018
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Autophagy (or type II programmed cell death, PCD), as opposed to apoptosis (or PCD type I), is characterized by excessive accumulation of autophagic vacuoles in the cytoplasm. This mediates destruction of cellular components and produces building blocks essential for cell survival. Yet, autophagy can also participate in the process of cell death, acting in parallel with apoptosis, or synergise with apoptosis by activating or amplifying death signals. Thus, autophagy appears to be able to have both cytoprotective properties but can also facilitate the process of cell death.
Supervisor: Georgopoulos, Nikolaos T. Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available
Keywords: R Medicine (General) ; RC0254 Neoplasms. Tumors. Oncology (including Cancer)