Use this URL to cite or link to this record in EThOS:
Title: Fully automated computer system for diagnosis of corneal diseases : development of image processing technologies for the diagnosis of Acanthamoeba and Fusarium diseases in confocal microscopy images
Author: Alzubaidi, Rania S. M.
ISNI:       0000 0004 7968 087X
Awarding Body: University of Bradford
Current Institution: University of Bradford
Date of Award: 2017
Availability of Full Text:
Access from EThOS:
Access from Institution:
Confocal microscopy demonstrated its value in the diagnosis of Acanthamoeba and fungal keratitis which considered sight-threatening corneal diseases. However, it can be difficult to find and train confocal microscopy graders to accurately detect Acanthamoeba cysts and fungal filaments in the images. Use of an automated system could overcome this problem and help to start the correct treatment more quickly. Also, response to treatment can be difficult to assess in infectious keratitis using clinical examination alone, but there is evidence that the morphology of filaments and cysts may change over time with the use of correct treatment. An automated system to analyse confocal microscopy images for such changes would also assist clinicians in determining whether the ulcer is improving, or whether a change of treatment is needed. This research proposes a fully automated novel system with GUI to detect cysts and hyphae (filaments) and measure useful quantitative parameters for them through many stages; Image enhancement, image segmentation, quantitative analysis for detected cysts and hyphae, and registration and tracking of ordered sequence of images. The performance of the proposed segmentation procedure is evaluated by comparing between the manual and the automated traced images of the dataset that was provided by the Manchester Royal Eye Hospital. The positive predictive values rate of cysts for Acanthamoeba images was 76%. For detected hyphae in Fusarium images, many standard measurements were computed. The accuracy of their values was quantified by calculating the percent error rate for each measurement and which ranged from 23% to 49%.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available
Keywords: Image processing ; Cornea ; Digital diagnostic ; Confocal microscopy ; Infectious keratitis ; Acanthamoeba ; Fusarium ; Corneal diseases