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Title: Remotely actuated polymeric nanocomposites for biomedical applications
Author: Brunner, Ileana Andrea Bonilla
ISNI:       0000 0004 7966 0879
Awarding Body: University of Oxford
Current Institution: University of Oxford
Date of Award: 2018
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The present work describes the synthesis, structural and mechanical characterisation of soft polymeric materials used for biomedical purposes. This thesis is separated in two parts: the first one pays special attention to natural polymeric hydrogels for Tissue Engineering (TE) described in chapter 3 and chapter 4 describes the synthesis of magnetically responsive nanocomposite hydrogels for TE. In this first part, I mainly focus on the mechanical characterisation of the synthesised materials. I use AFM microindentations to characterise them locally and oscillatory shear rheometry to characterise the bulk responses of the material, obtaining the reduced Young's modulus (E*), the storage G' and the loss G'' modulus respectively. Furthermore, in chapter 3, the assessment of the stability of microbeads made of alginate for modular TE is described, followed by a novel magneto-mechanical coupling observed for the first time in chitosan hydrogels. In the 4th chapter, I characterise the mechanical response of a chitosan-Fe3O4 nanocomposite with an enhanced magneto-mechanical coupling. The second part of this work (chapter 5) describes a simple synthesis of polymeric micro-ellipsoidal particles for torque generation assays in biomedicine. I characterise the rotation of these particles in comparison to commercially available spherical microparticles and their enhanced ability to follow low magnetic rotating fields.
Supervisor: Contera, Sonia Sponsor: STSM COST Action CA16122 ; CONACYT
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available