Use this URL to cite or link to this record in EThOS: https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.779435
Title: Pharmaceutical applications of stereolithography (SLA) 3D printing
Author: Robles Martinez, Pamela
ISNI:       0000 0004 7965 1315
Awarding Body: UCL (University College London)
Current Institution: University College London (University of London)
Date of Award: 2019
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Abstract:
3D printing is a technology that fabricates objects by consecutively placing layers of material based on an electronic design and, due to its ability to manufacture personalised objects on demand, it is rapidly growing in plenty of different areas including healthcare. Various technologies have been explored in Pharmaceutics, amongst these, stereolithography (SLA) offers the possibility to fabricate crosslinked polymeric matrices (via photopolymerisation) with a superior resolution while avoiding the need to use high temperatures. In this work SLA was used to produce dosage forms for Oral Controlled Release (OCR). First, the fabrication of drug-loaded hydrogels containing variable water content produced using two different photoinitiators (Diphenyl (2,4,6-trimethylbenzoyl) phosphine oxide and the water-soluble riboflavin-triethanolamine) was evaluated. SLA was successful in producing hydrogels; dissolution tests results showed that water content of up to 30% does not significantly change drug release rates, whereas the photoinitiator used does. Secondly, SLA was used to investigate the influence of geometry on drug release; complex shaped-tablets (cylinder, sphere, cube, pyramid, torus and multi-tori) were printed and the surface area to volume ratio (SA/V) was identified as a key factor determining drug release kinetics, as it increased so did the rate of drug release. Finally, the use of SLA for producing multi-layered polypills was tested. The method developed allowed the fabrication of polypills containing six model drugs for the first time. Modification of drug release was also possible by varying drug content, geometry and the inclusion of a diluent. Raman imaging showed the distribution of the drugs and dissolution tests exhibited different release kinetics for each formulation. SLA proved to be suitable to fabricate OCR dosage forms, it also showed to be flexible for incorporating multiple drugs and for easy modification of drug release, making it a potential pharmaceutical manufacturing method for medicine personalisation.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID: uk.bl.ethos.779435  DOI: Not available
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