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Title: A modular approach to the synthesis of stretched luciferin analogues for use in near infrared optical imaging
Author: Pacman, Steven James
ISNI:       0000 0004 7964 8984
Awarding Body: UCL (University College London)
Current Institution: University College London (University of London)
Date of Award: 2019
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The introduction to this thesis covers the original work by McElroy, which established the requirements for light emission from firefly luciferin, and then the eventual elucidation of it chemical structure and synthesis. The mechanism of light emission is then discussed and a brief overview of some of the uses of bioluminescence in biology is discussed. The limitations of firefly luciferin are described along with some of the methods and attempts to address the limitations The results and discussion section describes the various attempts and progress towards a new alkyne bridged luciferin analogue. The various attempts to produce a new synthetic route to infraluciferin are described along with the successful route. The synthesis of a new analogue using the new synthetic route to infraluciferin is then presented. The future work and conclusions section give a summary of the work left that still warrants more attention and the successful results that were attained. The experimental section provides procedures and data for all the relevant compounds from the research carried out.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available