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Title: Detection and phenotypic characterization of drug (metabolite)-specific t-cells from patients with drug-induced skin and liver injury and healthy donors
Author: Alhilali, Khetam Abdalsada Ali
ISNI:       0000 0004 7964 1862
Awarding Body: University of Liverpool
Current Institution: University of Liverpool
Date of Award: 2019
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Drug hypersensitivity reactions are unpredictable adverse drug reactions. They represent a considerable clinical problem and an obstruction to drug development. Delayed-type drug hypersensitivity reactions targeting skin and/or liver are thought to have an immune pathogenesis with drug-specific T-cells believed to play an important role in the initiation and regulation of tissue injury. The objective of this thesis was to explore the cellular basis of three forms of drug hypersensitivity reaction, namely, dapsone hypersensitivity syndrome, tolvaptan-induced liver injury and telaprevir-induced severe skin injury.
Supervisor: Naisbitt, Dean Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral