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Title: Evaluation of a dentine hybrid self-adhesive restorative material interface
Author: Abuljadayel, Roaa Abdulsalam
ISNI:       0000 0004 7963 9244
Awarding Body: King's College London
Current Institution: King's College London (University of London)
Date of Award: 2019
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Self-adhesive resin cements have become an integral part of luting of indirect restorations. Recently, a new formula as a derivative of this cement has been introduced as a self-adhesive, dual-cure, hybrid resin/glass ionomer (DC-HRI), bulk-fill coronal restorative material that could replace large amalgam restorations. These materials could be self-adhesive due to the acidic nature of their phosphorylated methacrylate monomers along with improved mechanical properties due to high silanated filler content. This thesis was constructed around three specific aims; Firstly, optical, mechanical and chemical characterisation of natural caries, partially demineralised dentine models against control sound dentine. Secondly, to investigate potential interfacial dentine remineralisation of the experimental material compared to a commercial highly viscous GIC (EQUIA Fill, GC, Tokyo, Japan) and a Bulk Fill resin composite (Filtek Bulk Fill, 3M, USA) bonded with a self-etch "Universal" adhesive. Thirdly, to examine the sealing and the adhesive properties of the new material compared to the control materials, when bonded to these different dentine substrates. The in-vitro demineralised dentine model, natural infected and affected carious dentine and sound controls were initially characterised using various advanced optical imaging techniques. These techniques included two-photon fluorescence microscopy, fluorescence lifetime imaging and second harmonic generation imaging (used as a stable correlative substrate reference), to assess optical changes before and after aging the samples. In addition, Raman spectroscopy was used to detect the mineral peak intensity changes. These non-invasive techniques allowed differentiation between the carious zones and other dental substrates without labelling, assisted by their Knoop microhardness readings. Tissue interactions with GIC and the experimental material resulted in significant changes in the optical properties of infected, affected and demineralised dentine. A significant increase in Raman mineral peak intensity was noticed with the demineralised dentine and caries-affected dentine due to the possible mineral precipitation and ionic exchange. In addition, carefully calibrated fluorescent dye micro-permeability experiments (a direct indicator of water uptake within materials and interfaces), in conjunction with specific material labelling through the dentine interface, revealed inadequate Abstract 3 sealing with all the material groups. However, better adhesion was observed with the in-vitro demineralised dentine group. This thesis demonstrates the successful use of non-invasive multimodal evaluation techniques in determining the changes in dentine properties and in investigating potential remineralisation benefits from the use of an experimental self-adhesive bulk-fill hybrid restorative material.
Supervisor: Watson, Timothy F. ; Banerjee, Avijit Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available