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Title: C-reactive protein in periodontal disease
Author: Aziz, Sabah Isaac
Awarding Body: University of Edinburgh
Current Institution: University of Edinburgh
Date of Award: 1993
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The aim of this study was to investigate the role of the acute phase protein (C-reactive protein) as a possible diagnostic aid in periodontal disease activity using gingival crevicular fluid (GCF), saliva and serum, and to investigate the value of measuring CRP in predicting periodontal disease activity. Fifty-four patients with chronic periodontitis and twenty five healthy dental students (controls) from Edinburgh Dental Hospital and School were recruited for the study, and were seen at two months intervals over one year. Clinical parameters were recorded, microbiological samples taken and biological fluids sampled at each of the six examinations over the study period. GCF, saliva and serum samples were analysed for CRP levels using a modified ELISA technique developed during the study. The clinical, microbiological and CRP data was subjected to statistical analysis using a general statistic package. The results confirm the presence of CRP in GCF for both the patient and control groups, and this is the first report for CRP being present in GCF. The results indicated a significant positive correlation between attachment level change and changes in CRP levels for both short and long term. However, within the limitations of this study, CRP levels in GCF failed to predict periodontal disease activity as measured by attachment level loss. It is concluded that CRP is present in GCF and that its level in GCF is significantly associated with attachment level change. The level of CRP in GCF cannot be used as a diagnostic aid in predicting periodontal disease activity over a period of two months or one year. It is suggested that further investigation should be carried out to monitor CRP levels within a very short time period as the level rapidly increases during chronic inflammation and rapidly returns to a normal level when the inflammatory stimulus subsides.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available