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Title: A pathological study of liver disease in animals
Author: Mackay, J. M. K.
Awarding Body: University of Glasgow
Current Institution: University of Glasgow
Date of Award: 1960
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The thesis is divided into two sections. The first of these describes the occurrence and isolation of a strain of ectromelia virus from an epidemic in which skin lesions were not a notable feature. The outstanding feature at necropsy in these cases was a regularly occurring hepatitis. The identity of the agent was confirmed by means of egg inoculation, virus neutralisation and haemagglutination tests, and it was considered that the disease might serve as a useful experimental model of infective hepatitis. The second section of the theses deals with the effects of environmental factors on the development of the diseased produced by the virus. Protein deficient diets were selected on the basis of their ability to produce dietetic necrosis in rats. Two such diets which differed only in the source of casein used failed to influence adversely the development of hepatitis due to the virus. The effect of a cold environment was next investigated and it was demonstrated that the 50 per cent lethal dose end-point was much higher in the cold environment. The results were highly significant and indicated that a hundred to a thousand times as much virus is required to kill approximately 50 percent of mice in the warm environment.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available