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Title: Photochemical studies in the steroid series
Author: Williams, Ivor Anthony
Awarding Body: University of Glasgow
Current Institution: University of Glasgow
Date of Award: 1965
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The ultraviolet irradiation of hecegenin apostate has been shown to give two products,. Lumihecagenin acetate, 3beta-acetexy=12, 13-sece-5alpha, 25D-spirest-13-en-12one, which is the initial product, is converted by oridative cyclisation into 14alpha = hydrexyhecagenin 3beta=acetate, 3?=acetex-14+hydrexy-5alpha, 25D-spirestan-12-one. Prolanged irradiation of hacegenin acetate, er of lumihecogenin acetate, gives a second isemeric productm "phetehecohenin acetate", 3beta-acetoxy-12alpha, 14alpha-epexy-5alpha, 25D-spirestan. Treatment of lumihecegenin acetate or photohecegenin acetate with boren triflueride-other complex gives a mioxture of products, one products being 3beta-acetoxy-12alpha-hydroxy-5alpha, 25D-spirest-14-en. The other product from this reaction is believed to be a C-home-exastereid. Epexidation of the Delta14-12alpha-ol gives A 14alpha, 15alpha-opexide which on reduction with lithium aluminium hydride affords the same trial as is obtained on similar reduction of 14alpha-hydroxy-hecegenin.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available