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Title: Aspects of adrenal function in children
Author: Hamilton, William
Awarding Body: University of Glasgow
Current Institution: University of Glasgow
Date of Award: 1967
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The research work comprising this thesis is partly clinical and partly biochemical. The clinical aspects concern the diagnosis and treatment of congenital adrenal hyperplasia and an assessment of some children of small stature. Most of these patients have been in Professor J.H. Hutchison's Wards at the Royal Hospital for Sick Children, Glasgow, and I am indebted to him for allowing access to this clinical material. Indebtedness is also due to Ur. James R. Davidson, General Director of Quarrier's Homes, Bridge of Weir, in Whose care were some of the children of small stature. The biochemical aspect of the thesis is a study of urinary steroids in cases of congenital adrenal hyperplasia. While principally to assist in their management, the investigation was extended to urinary aldosterone and 17-oxosteroid studies. In the children of small stature, the metabolism of hydrocortisone has been assessed by the estimation of the urinary metabolites of this compound. From the findings, hepatic reductase activity and 11-oxidation of hydro cortisone have been deduced. In Chapter 4 there is a critical analysis of the value of urinary aldosterone estimation in infancy and childhood.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (M.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available