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Title: The origin, turnover and removal of normal glomerular basement membrane
Author: Walker, Frederick
Awarding Body: University of Glasgow
Current Institution: University of Glasgow
Date of Award: 1971
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A comprehensive account of the natural history of normal glomerular basement membrane is prerequisite to elucidating the pathogenesis of numerous renal diseases. The experimental argyric technique was investigated, adapted and applied in a long term sequential, electron microscopic study of normal glomerular basement membrane in the rat. The results demonstrate that a major component of glomerular basement membrane is secreted by the visceral epithelial cells. This component is laid down on the epithelial side and slowly moves towards the endothelial side of the basement membrane as new basement membrane material continues to be secreted. The old basement membrane material is removed from the endothelial aspect of the membrane and passes by way of the lamina rara interna to the mesangial matrix for subsequent ingestion by the mesangial cells. This process is continuous and slow; the time for complete renewal of the glomerular basement membrane in the rat is of the order of twelve months. Secretion of this component, by the epithelial dells, is effected by a vascular-coated pit mechanism and removal, by the mesangial cells, is effected by a phagocytic mechanism. The results further indicate the presence of a second component in glomerular basement membrane. This second component is probably of endothelial origin and has a much faster turnover rate than the main, or epithelial derived, component. Study was also made of glomeruli from two cases of human argyria and though the observations perforce are limited, the results show that human glomerular basement membrane has a natural history essentially similar to rat glomerular basement membrane. On the basis of these experimental observations, correlated with the results of previous investigations, a model of the functional morphology of glomerular basement membrane is proposed. The potential applications of this model are briefly indicated.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (M.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available