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Title: Venous thrombosis and women's health : identification of risk factors and long terms effects
Author: McColl, Mark D.
Awarding Body: University of Glasgow
Current Institution: University of Glasgow
Date of Award: 1999
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Venous thromboembolism (VTE) remains an important cause of morbidity and mortality, with well-recognised inherited and acquired risk factors. Women are particularly at risk of this condition because of pregnancy, the use of combined oral contraceptive pills, and hormone replacement therapy. A number of long-term sequelae may occur following an episode of VTE in women, such as development of the post- thrombotic syndrome, restriction of future contraceptive choice, bleeding events related to anticoagulants, and recurrence of thrombosis. In recent years there has been a marked increase in our understanding of genetic risk factors important for the development of VTE, and of their interaction with acquired risks. In particular, the description of the factor V Leiden and (more recently) prothrombin 202 lOA mutations have highlighted common genetic variations that are associated with a modest increased risk of thromboembolism. These genetic mutations may also be associated with other conditions that are associated with coagulation activation, such as preeclampsia. Thrombophilia is a rapidly expanding and complex field, and undoubtedly new abnormalities will be described within the next few years.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (M.D.) Qualification Level: Doctoral