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Title: The role of insulin sensitising agents in polycystic ovary syndrome
Author: Harborne, Lyndal Ruth
Awarding Body: University of Glasgow
Current Institution: University of Glasgow
Date of Award: 2005
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Polycystic Ovary Syndrome (PCOS) is a common disorder of chronically abnormal ovarian function and hyperandrogenism whose clinical effects include oligomenorrhoea and hirsutism. It has been determined that the principal underlying defect is hyperinsulinaemia secondary to insulin resistance. Use of insulin sensitising agents in women with PCOS is becoming increasingly widespread. Trials with metformin, one such agent, enthusiastically report a wide range of benefits in metabolic, reproductive and clinical measures. We have shown that metformin treatment of women with polycystic ovary syndrome has the following effects; o It may be more effective than Dianette in the treatment of hirsutism. o It is effective in reducing weight and improves lipid profiles in obese women with oligomenorrhea or a raised free androgen index. o It reduces serum mullerian inhibiting substance in the circulation after protracted treatment (> 4months). o It has effects upon adrenal androgen biosynthesis manifested by a reduction in circulating basal concentrations of 170HP.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (M.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available