Use this URL to cite or link to this record in EThOS: https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.775014
Title: Exploring new methodologies for the synthesis of garlic metabolites
Author: Silva, Filipa
ISNI:       0000 0004 7962 2127
Awarding Body: Cardiff University
Current Institution: Cardiff University
Date of Award: 2019
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Abstract:
The therapeutic benefits of garlic are related to the high concentrations of organosulfur compounds present. Allicin is the main biologically active component of garlic extracts. Due to its instability, it rapidly decomposes into a variety of organosulfur compounds. Among the decomposition products of allicin, ajoene is biologically more stable and active. In this thesis, an efficient total synthesis of ajoene was accomplished from easily available starting materials. In addition, the protocol allowed the synthesis of several ajoene derivatives. Moreover, the protocol proved to be amendable to scale-up and provided 169g of ajoene in ~90% purity. A second synthetic protocol for the synthesis of ajoene from simple and easily available starting materials has also been investigated in batch and in flow. Finally, a rapid, versatile and selective oxidation system has been developed for a variety of sulfides and disulfides. The method allowed the synthesis of allicin in moderate yields.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID: uk.bl.ethos.775014  DOI: Not available
Keywords: QD Chemistry
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