Use this URL to cite or link to this record in EThOS: https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.771787
Title: Development of self-adhesive, remineralising and antibacterial composites and the effect of these properties on the bond strength, monomer conversion and resin tag formation in human dentine
Author: Tzelepi, Zoi
ISNI:       0000 0004 7659 8790
Awarding Body: UCL (University College London)
Current Institution: University College London (University of London)
Date of Award: 2018
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Abstract:
Dental composite materials have been used for over 50 years for the restoration of a tooth cavity and nowadays they largely replace the use of amalgam. Current dental composites though, have multiple weaknesses that can lead to failure of the restorations such as recurrent caries and multiple step placement. Aims: The aim of this project was to develop new novel composite formulations that promote remineralising, antibacterial and self-adhesive properties, which could potentially improve the above-mentioned disadvantages of the dental composites, to assess the effect of the new components on the bond strength. It also aimed to assess if the final formulation SU2, has sufficient monomer conversion for single step bulk placement and can form resin tags into carious versus affected dentine. Materials and methods: Three experimental formulations (A6, C2, SU2) with powder part containing different amounts of MCPM and polylysine and monomer consisting of UDMA, PPGDMA, 4META and CQ. The bond strength of two new formulations was assessed and compared to commercial Z250 and Fuji II & IX glass ionomer and monomer conversions (MC) at depths of 2 mm with 20 s versus 4 mm with 40 s light exposure were determined using ATR FTIR for one experimental formulation. A commercial composite (Z250, 3M) and a resin modified glass ionomer cement (Fuji II-LC, GC) were used as controls (n=3). Sound adult molars and premolars were collected and embedded into self-curing resin blocks to assess the shear bond strength in human dentine. Results: The shear bond strength of C2 found to be higher compared to A6 when no etch or i-bond were used. The commercial Z250 had the lowest bond strength without etch and bond, but was still best performing when etch and bond were used together, prior to the application of the material. For the SU2 formulation 75% and 70% monomer conversion was obtained at 2mm and 4mm depth respectively. For Z250, results were 56% and 53% and for Fuji II-LC 90% and 93% respectively. For the experimental but not commercial material, resin tag formation up to 200 micron in length was observed in both highly infected dentine and the underlying disease affected dentine by the various microscopic techniques.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID: uk.bl.ethos.771787  DOI: Not available
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