Use this URL to cite or link to this record in EThOS:
Title: Design of gold nanoparticles with controllable phase transfer properties
Author: Hill, Alexander Paul
ISNI:       0000 0004 7656 5614
Awarding Body: University of Liverpool
Current Institution: University of Liverpool
Date of Award: 2018
Availability of Full Text:
Access from EThOS:
Access from Institution:
This project was aimed at initiating the development of gold nanoparticles (AuNP) functionalised in such a way that allowed for the mimicking of biological systems, those that effectively couple uphill processes with downhill processes to transfer charge across an organic interface (the phospholipid membrane). The hope was to utilize a specific functional group adhered to the gold surface to achieve cation transfer, whilst attempting to achieve electron transfer via the exposed gold core. Via the application of the cyclic oligomers better known as crown ethers, taking advantage of their selective cation association properties, the transfer of cations from the aqueous phase to the organic phase via the use of small functionalised gold nanoparticles was successfully demonstrated. The most effective system (18-Crown-6-modified AuNPs) was identified via comparative studies between the rates of phase transfer with various cations. These studies were then later used to achieve complimentary cation transfer across an artificial membrane, evidenced by both cryo-TEM and fluorescence spectroscopy data. This idea was then taken further by implementing the same crown ether (18-Crown-6) upon larger AuNPs (7.5nm), a gold core volume with a much greater potential for allowing the transfer of electrons. Not only did AuNPs modified in this way result in similar phase transfer and membrane adherence of the 3nm particles, but also presented a unique process; entropically driven reversible agglomeration with changes in temperature. This system was characterized in full to further advance our understanding, to maximise the potential of using it for both cation and electron transfer. Preliminary work on the interaction of the larger AuNPs with a redox couple (potassium ferro/ferri cyanide) was briefly undertaken, in the hopes of transferring an electron from one redox partner to the other, via the coupling of a downhill reaction, the formation of Barium Sulphate. However, this system was not fully realised within this thesis, but a solid foundation was laid for future work.
Supervisor: Brust, Mathias Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral