Use this URL to cite or link to this record in EThOS: https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.770937
Title: An investigation of the potential biocidal activity of microbial biosurfactants against bacteria important in oral and personal hygiene
Author: Elshikh, Mohamed
ISNI:       0000 0004 7655 3664
Awarding Body: Ulster University
Current Institution: Ulster University
Date of Award: 2017
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Abstract:
Biosurfactants are natural surfactants produced from different microorganisms and plants. They are receiving increasing industrial attention due to; having lower toxicity than surfactants in use; being biodegradable and; the increasing demand for organic healthcare and hygiene products. The main theme of this work was to investigate potential antimicrobial efficacy of well characterised biosurfactants for future use in healthcare and hygiene products, with a focus on oral hygiene. Chapters 2 and 3 review work using biosurfactants for oral hygiene and cosmetics, directing research in contributing work to the gap realised. In Chapter 4 an accurate microdilution method was developed (using guidelines from the Clinical Laboratory Standard Institute), to obtain a precise understanding of antimicrobial efficacy of biosurfactants. This method was then used to investigate a wide range of biosurfactants (acquired and produced in-house). Chapters 5 and 6 discussed the potential role that some biosurfactants (namely rhamnolipids JBR425, lactonic sophorolipids and long chain rhamnolipids from non- pathogenic strains), can play in oral hygiene. Besides antibacterial efficacies, their ability to prevent/disrupt oral pathogenic biofilms and the combination effect of biosurfactant with standard antimicrobials/antibiotics, were also investigated. The role of highly purified congeners in combating oral cancer and the permeabilization and reactive oxygen species formation in inhibition/killing microorganisms under study, was also reported. Chapter 7 discussed the antiadhesive role of rhamnolipids on silicone material, through optimizing coating methods. Chapter 8 discussed rhamnolipids (from a high yield industrial producer), for antimicrobial effect against strains relevant to human hygiene and their antiadhesive role in protecting medical grade stainless-steel. The thesis provides significant well-defined data that serves as a platform for further in vitro and in vivo pharmaceutical applications, where increasing demand on hygiene and healthcare products, less dependent on compounds of synthetic origin, has positive implications towards a greener environment.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID: uk.bl.ethos.770937  DOI: Not available
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