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Title: Novel strategies for synthesising and labelling the heteroatom-trifluoroethyl motif
Author: Hyde, Stephen
Awarding Body: University of Oxford
Current Institution: University of Oxford
Date of Award: 2018
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The expansion of methodologies to access fluorinated molecules is vital to the pharmaceutical and agrochemical industry. Novel protocols will complement existing routes to accessing proven useful fluorinated motifs, and for accessing new chemical space. Such fluorinated scaffolds may be [18F]-radiolabelled, generating tracers which may be used to produce medical images through Positron Emission Tomography (PET). Improvement in [18F]-radiolabelling techniques will simplify access to current PET tracers and allow the development of original tracers, potentially enhancing image quality or permitting images of a wider range of clinical problems.
Supervisor: Gouverneur, Véronique Sponsor: AstraZeneca
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available