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Title: A study of the impact of stroke comorbidities on the dynamic cortical collateral perfusion following acute ischaemic stroke
Author: Biose, Ifechukwude Joachim
ISNI:       0000 0004 7654 9585
Awarding Body: University of Glasgow
Current Institution: University of Glasgow
Date of Award: 2018
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Acute hyperglycaemia and chronic hypertension are known risk factors of stroke and are often present following ischaemic stroke onset. These stroke comorbidities worsen neurological outcome following stroke in humans and accelerates the growth of cerebral ischaemic lesion in experimental models. Recent evidence indicates that the functional capacity of cerebral collateral vessels is critical for the survival of the ischaemic penumbral before and following the administration of available endovascular therapies. However, the influence of stroke comorbidities on cerebral collateral flow dynamics following stroke is not well understood. Therefore, the studies detailed in this thesis aimed to determine the impact of acute post-stroke hyperglycaemia and chronic hypertension on the dynamic recruitment of cortical collateral perfusion following focal cerebral ischaemia. In addition, the efficacy of a potent vasodilator was evaluated for its potential flow enhancing properties following ischaemic stroke in the presence of chronic hypertension.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available
Keywords: RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry