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Title: Molecular mechanisms of YAP signalling in the context of cancer
Author: Xie, Bailu
ISNI:       0000 0004 7660 2390
Awarding Body: University of Bath
Current Institution: University of Bath
Date of Award: 2019
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Over the last 40 years, little progress has been made in improving the treatment outcomes of pancreatic ductal adenocarcinoma (PDAC). The desmoplastic and hypo-vascular microenvironment of this cancer limits access to therapeutic strategies. Stellate cells, comprising the majority of stroma and secreting large amount of extracellular matrix (ECM), have been suggested to provide a supportive environment for pancreatic cancer whilst playing a suppressive role in cancer growth. In order to identify strategies capable of modulating pancreatic cancer stroma without promoting cancer growth, it is imperative to establish an in vitro human cancer model resembling the human cancer microenvironment.
Supervisor: De Bank, Paul ; Mackenzie, Amanda ; Ward, Stephen ; Mrsny, Randall Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available