Use this URL to cite or link to this record in EThOS: | https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.767559 |
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Title: | Site selective catalytic C-H functionalisation | ||||||
Author: | Leitch, Jamie |
ISNI:
0000 0004 7659 7552
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Awarding Body: | University of Bath | ||||||
Current Institution: | University of Bath | ||||||
Date of Award: | 2017 | ||||||
Availability of Full Text: |
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Abstract: | |||||||
Harnessing site selectivity in C-H functionalisation remains one of the greatest challenges in modern catalysis. In order to differentiate electronically and sterically similar C-H bonds, a variety of pioneering methods have been developed in recent years. One of the key developments is the use of Lewis basic directing groups to selectively direct a metal centre. The results herein report the manipulation of directing group chemistry to allow selective ortho, meta and para C-H functionalisation of arenes. Chapter 1 reports the developments in moving beyond ortho-selectivity in transition metal catalysed C-H functionalisation chemistry. Chapter 2 reports the use of the biologically relevant oxazolidinone and hydantoin heterocycles as weakly coordinating directing groups in ruthenium catalysed ortho-C-H alkenylation methodology. Chapter 3 reports the application of ruthenium catalysed σ-activation to the remote C-H functionalisation of indoles at the C6 position and carbazoles at the C4 position. Chapter 4 reports the manipulation of site selective cyclometalation and its application in the para-C-H alkylation of aniline derivatives.
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Supervisor: | Frost, Christopher | Sponsor: | Syngenta | ||||
Qualification Name: | Thesis (Ph.D.) | Qualification Level: | Doctoral | ||||
EThOS ID: | uk.bl.ethos.767559 | DOI: | Not available | ||||
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