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Title: Wavelet analysis of nonstationary circadian time series
Author: Hargreaves, Jessica
Awarding Body: University of York
Current Institution: University of York
Date of Award: 2018
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Rhythmic data are ubiquitous in the life sciences, with biologists needing reliable statistical tools for the analysis of such data. When these signals display rhythmic yet nonstationary behaviour, common in many biological systems, the established methodologies are often misleading. Chapter 2 develops and tests a new method for clustering nonstationary rhythmic biological data. The method combines locally stationary wavelet time series modelling with functional principal components analysis and thus extracts time-scale patterns useful for identifying common characteristics. We demonstrate the advantages of our methodology over alternative approaches by means of a simulation study and for real circadian data applications. Motivated by three complementary applications in circadian biology, Chapter 3 develops new reliable statistical tests to identify whether a particular experimental treatment has caused a significant change in a rhythmic signal that displays nonstationary characteristics. As circadian behaviour is best understood in the spectral domain, we develop novel hypothesis testing procedures in the (wavelet) spectral domain, which facilitate the identification of three specific types of spectral difference. We demonstrate the advantages of our methodology over alternative approaches by means of a comprehensive simulation study and for real data applications, involving both plant and animal signals. Chapter 4 investigates the effect of industrial and agricultural pollutants on the plant circadian clock. We examine the impact of exposure to a comprehensive range of environmentally relevant pollutants by utilising the methodologies developed in Chapters 2 and 3. Our findings indicate that many of the tested chemicals have an effect on the plant circadian clock, most of which would have remained undetected by classical methods overlooking nonstationarity. The results of Chapter 4 demonstrate the additional insight gained by using the appropriate methodologies, as developed in Chapters 2 and 3, and also have important implications for understanding environmental ramifications associated with soil pollution.
Supervisor: Knight, Marina ; Pitchford, Jon ; Davis, Seth Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available