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Title: The application of intramolecular N-acyliminium cyclisation strategies towards biologically active heterocycles
Author: Towler, Joannah M. R.
Awarding Body: Loughborough University
Current Institution: Loughborough University
Date of Award: 2011
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We describe the application of N-acyliminium cyclisation strategies to access a range of heterocycles with potential for biological activity. We have described an asymmetric approach towards the anti-tumour pyrroloisoquinoline alkaloid (R)-(+)-crispine A. We have achieved a synthesis of the pyrrolo[2,1-a]benzazepine template which is a sub-unit of the Homoerythrina alkaloids, and the functionalised dodecahydrobenz[a]indolo[3,2-h]quinolizine template, which is a sub-unit of the manadomanzamine alkaloids. In addition, we have described an asymmetric synthesis of the α-hydrazino pyrroloisoquinoline ring system, towards the synthesis of conformationally restricted peptidomimetics.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Eng.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available