Use this URL to cite or link to this record in EThOS: https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.762676
Title: Microbubble distribution and incorporation in an ex-vivo perfused porcine
Author: Alzaraa, Ahmed
ISNI:       0000 0004 7657 9450
Awarding Body: University of Leicester
Current Institution: University of Leicester
Date of Award: 2018
Availability of Full Text:
Access from EThOS:
Access from Institution:
Abstract:
This thesis describes the behaviour and distribution of microbubbles using ultrasound and the relevant histological changes that occur upon the application of microwave energy in an exvivo perfused porcine liver model. The research was conducted in the laboratories of the Department of Molecular Medicine and Transplant Biology at Leicester General Hospital. The department has a long-standing interest in bio-artificial liver and basic investigation of tissue ablation techniques. To do this, the department runs an ex-vivo porcine liver model and has considerable experience in this field. This model is perfused with autologous blood. It accurately simulates the in-vivo situation, but removes some of the extraneous and confounding components associated with normal physiological and metabolic responses. This allows for extremely careful and reproducible adjustments of inflow and outflow parameters and is ideal for basic investigation of blood flow, and anything affected by this including substances infused into the liver.
Supervisor: Lloyd, David ; West, Kevin ; Morgan, Bruno Sponsor: Not available
Qualification Name: Thesis (M.D.) Qualification Level: Doctoral
EThOS ID: uk.bl.ethos.762676  DOI: Not available
Share: