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Title: The role of impaired serum bactericidal activity in chronic Pseudomonas aeruginosa infection in non cystic fibrosis bronchiectasis
Author: Whitters, Deborah
ISNI:       0000 0004 7432 4139
Awarding Body: University of Birmingham
Current Institution: University of Birmingham
Date of Award: 2018
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Non Cystic Fibrosis bronchiectasis is characterised by perpetual neutrophilic inflammation in the lungs. The ongoing vicious cycle of bronchiectasis leads to further damage to already damaged airways and is a culmination of repeated infection, inflammation and failure of the host response to maintain sterility of the airway, despite a sophisticated innate and adaptive immune system. Pseudomonas aeruginosa commonly colonises the lungs of patients with bronchiectasis. I hypothesised that the concept of inhibitory antibodies in the serum may be a feature of Pseudomonas aeruginosa colonisation through a specific interaction between the host adaptive immune system and strain specific features. Here I have identified a mechanism where some patients colonised with Pseudomonas aeruginosa produce IgG2 antibodies specifically against the O antigen of bacterial LPS, which rather than promote complement-mediated killing actually inhibits it.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (M.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available
Keywords: R Medicine (General)