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Title: Immune activation in alpha-1 antitrypsin deficiency related and usual chronic obstructive pulmonary disease
Author: Hampson, Judith Anne
ISNI:       0000 0004 7432 3523
Awarding Body: University of Birmingham
Current Institution: University of Birmingham
Date of Award: 2018
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A polyclonal increase in free light chains (FLCs) has been observed in a number of chronic inflammatory and autoimmune conditions and may be considered a biomarker of adaptive immune activation. The aim of this study was to examine whether FLCs could be a useful clinical biomarker in alpha-1 antitrypsin deficiency (A1ATD) and chronic obstructive pulmonary disease (COPD). Combined (\(\kappa\) & \(\lambda\)) FLCs (cFLCs) were measured in patients with AlATD and usual COPD in the stable state and assessed for association with clinical phenotype, disease severity, bacterial colonisation and mortality. The relationship of FLCs to total immunoglobulin levels was also examined in the COPD cohort. In addition, FLCs were measured in a small cohort of patients with bronchiectasis to further examine the relationship to bacterial colonisation. Circulating cFLCs were static in the stable state in both A1ATD and usual COPD. Levels were significantly higher in patients with chronic bronchitis and airway bacterial colonisation in AlATD. After adjusting for renal function and age the relationship between cFLCs and lung function was weak, however cFLC levels greater than normal significantly associated with mortality in both COPD cohorts. In conclusion, cFLCs may be a promising biomarker for risk stratification in AlATD and COPD.
Supervisor: Not available Sponsor: Grifol
Qualification Name: Thesis (M.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available
Keywords: QR180 Immunology