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Title: The efficacy of modern remineralising therapies containing calcium phosphate in remineralising enamel subsurface lesions
Author: Alotaibi, Shaikhah M. A. M.
ISNI:       0000 0004 7431 1004
Awarding Body: University of Leeds
Current Institution: University of Leeds
Date of Award: 2018
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Aims: To investigate in vitro the effect of Calcium Phosphate delivering technologies: Tooth Mousse (10% w/v CPP-ACP), MI paste Plus (10% w/v CPP-ACP, 900 ppm F), Clinpro 5000 (Tri-Calcium Phosphate, 5000 ppm F), Clinpro Tooth Crème ( Tri-Calcium Phosphate, 950 ppm F) in the remineralisation of artificial enamel subsurface lesions of bovine teeth and compare it with the effect of 1450 ppm F, 5000 ppm F, and 0 ppm F toothpastes using Quantitative Light-induced Fluorescence (QLF) technology. Materials and Methods: Artificial enamel subsurface lesions were created in bovine enamel slabs (N=182) which were assigned randomly to seven groups; (1) Fluoride-free Toothpaste (negative control), (2) 1450 ppm F toothpaste (positive control), (3) 5000 ppm F toothpaste, (4) 1450 ppm F toothpaste + Tooth Mousse (10% w/v CPP-ACP), (5) 1450 ppm F toothpaste + MI Paste Plus (10% w/v CPP-ACP, 900 ppm F), (6) Clinpro 5000 (Tri-Calcium Phosphate, 5000 ppm F), and (7) Clinpro Tooth Crème ( Tri-Calcium Phosphate, 950 ppm F). All the experimental products were used according to the manufacturer recommendation of dosage. The enamel slabs were cycled for 28 days, QLF images were taken at the baseline and at the endpoint of the experiment. Data analysis was carried out using one-way analysis of variance (One way ANOVA). Results: There were significant improvements in QLF values with all remineralising agents at the end of the study compared with baseline values within each group (P < 0.05). All groups showed a statistically significant improvement in ΔQ and Area of the lesion values compared with negative control (0 ppm fluoride) (P < 0.05). In term of ΔF values measurement, Clinpro Tooth crème was significantly more effective than high fluoride toothpaste (5000 ppm F) (P < 0.05). 5000 ppm fluoride toothpaste was not different significantly to either Clinpro 5000 or the fluoride-free toothpaste (P > 0.05). Conclusion: All group products were significantly more effective as remineralising agents of artificial early enamel subsurface lesions as compared with the negative control 0 ppm F. Calcium Phosphate delivering technologies; CPP-ACP with and without fluoride and Tri-Calcium Phosphate products were as effective as fluoridated toothpastes (1450 ppm F and 5000 ppm F) in remineralising artificial early enamel subsurface lesions. Tooth Mousse was as effective as MI Paste Plus when used in conjunction with 1450 ppm F toothpaste in remineralising artificial early enamel subsurface lesions in bovine teeth assessed using QLF technology.
Supervisor: Tahmassebi, Jinous Sponsor: Not available
Qualification Name: Thesis (D.Paed.Dent.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available