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Title: Synthetic routes to 9-azasteroids
Author: Eason, John M. M.
Awarding Body: Keele University
Current Institution: Keele University
Date of Award: 1975
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Syntheses of azasteroids both from natural steroids and from precursors bearing a nitrogen atom are reviewed. The present research was directed towards the preparation of suitable tricyclic compounds possessing the future A-,B- and D-rings of a 9-azasteroid system which were suitably substituted for the construction of ring C of the azasteroid system with ring A-aromatic. The first part of this work describes the synthesis of a tricyclic compound possessing a suitable side chain on the future D-ring for construction of the C-ring but the low yield of this compound proved prohibitive. The second part concerns the attempted preparation of a tricyclic compound possessing an aromatic substituent on the future D-ring which was suitable for formation of the C-ring. The last section describes the synthesis and stereochemistry of A-,B- and D-ring azasteroid precursors which possessed a substituent attached to the nitrogen atom of the future B-ring suitable for the formation of the C-ring and a leaving group attached to the future D-ring. Synthesis of the C-ring of these compounds all proved unsuccessful.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available
Keywords: QD Chemistry