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Title: Developing whole-body magnetic resonance imaging biomarkers for the assessment of haematological malignancies
Author: Latifoltojar, Arash
ISNI:       0000 0004 7429 2712
Awarding Body: UCL (University College London)
Current Institution: University College London (University of London)
Date of Award: 2018
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Whole body magnetic resonance imaging (WB-MRI) is being recognised as an alternative to conventional computed tomography, isotope bone scan and PET-CT scan. Advances in MR imaging have enabled sophisticated whole body protocols interrogating and imaging different facets of tumour biology. Furthermore, these multi-sequence WB-MRI protocols can be applied within patient friendly examination times. Qualitative and quantitative evaluation of WB-MRI examinations can now readily be performed, and form the focus of ongoing research into clinical utility for disease staging and response assessment. Quantitative WB-MRI research has mainly concentrated on diffusion weighted imaging (DWI) derived apparent diffusion coefficient (ADC), a parameter broadly representative of tumour cellularity. This thesis focuses on evaluating WB-MRI in the setting of lymphoma and multiple myeloma (haematological malignancies) through a series of translational imaging biomarker developmental studies. The first study retrospectively evaluates the diagnostic accuracy of WB-MRI (performed at 1.5 T) for the staging of paediatric Hodgkin’s lymphoma (HL) (Chapter 3) and determines ADC quantitative thresholds for disease detection (Chapter 4). Following this, a clinical trial of WB-MRI with prospective application of quantitative ADC thresholds for staging and response assessment of paediatric HL is described (Chapter 5). The final 3 chapters describe the WB-MRI studies conducted at 3.0 T – exploring the potential value of higher field strengths, and the reliability of novel quantitative imaging biomarkers for the diagnosis and response assessment of lymphoma and multiple myeloma.
Supervisor: Punwani, S. Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available