Use this URL to cite or link to this record in EThOS:
Title: Development of a novel rearrangement and synthetic approaches towards (-)-Nakadomarin A
Author: Regentová, Dominika
ISNI:       0000 0004 7428 7964
Awarding Body: University of Nottingham
Current Institution: University of Nottingham
Date of Award: 2014
Availability of Full Text:
Access from EThOS:
This thesis is split into two sections describing syntheses of heterocyclic systems. The introduction gives a brief discussion on heterocycles and their uses as drugs. The first section is devoted to sulfoximines and their preparation and uses. The approach described in this thesis is a one-pot procedure from sulfinimines and methyl-2-bromobutenoate via an Aza -Darzens reaction, giving tri-substituted aziridines, which undergo a radical-based rearrangement to form sulfoximines. Different groups have been tested and the yields were significantly improved in comparison with the two-step procedure. This novel approach gives easy access to cyclic sulfoximines. From here sulfoximines could be functionalised, reduced or deprotected and used for the synthesis of natural products.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available