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Title: Using pharmacokinetic and pharmacodynamic techniques to optimize dosing of antifungal agents for serious and life-threatening fungal infections
Author: Kovanda, L. L.
ISNI:       0000 0004 7428 4122
Awarding Body: University of Liverpool
Current Institution: University of Liverpool
Date of Award: 2017
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The aim of this thesis is to describe how the use of pharmacokinetic and pharmacodynamic techniques can provide a better understanding of the optimal use of antimicrobial agents. In vivo animal experimental models and clinical PK-PD datasets for three systemically administered antifungal agents, isavuconazonium sulfate (active moiety isavuconazole), micafungin, and VL-2397, are used to accomplish this goal.
Supervisor: Hope, W. W. Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral