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Title: The effect of roller compaction and tableting stresses on pharmaceutical tablet performance
Author: Rajkumar, Arthi D.
ISNI:       0000 0004 7428 2047
Awarding Body: University of Sheffield
Current Institution: University of Sheffield
Date of Award: 2018
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For tablets made by roller compaction the relationships between formulation composition, manufacturing conditions and in-vitro performance were examined. Two filler materials with different characteristics were studied. During tablet production, two main stresses are experienced by a material. The first stress occurs during granulation and the second stress during tableting. These stresses were investigated in terms of the tablet properties and disintegration behaviour. Roller compaction granulation, a continuous dry granulation process, was used to produce granules. The granules were then compacted using varying tableting stresses. The tablets were characterised by their porosity and tensile strength (i.e. compactibility), and were also examined using X-ray to determine the internal tablet structure. The tablet internal structure indicated that the final tablet compactibility was dependent on the RC stress used, which governs the consequent granular properties. The granular material is then affected by the tableting stress used depending on the granular properties and the magnitude of the stress. The tableting stress was found to crush and bond the granular material differently, depending on the how compacted the granular material is. Two different particle imaging methods, as well as the standard USP method, were employed to determine which method was most capable of distinguishing the effects of processing condition variation on tablet disintegration performance. The methods were evaluated to determine their effectiveness at monitoring disintegration and the information which is able to be gained from them. By using imaging methods to examine tablet disintegration, quantifiable information regarding the processes which occur during disintegration was observed, including the particle release and change in tablet area with time. It was found that the tableting stress has a greater influence on the tablet disintegration than roller compaction stress. The findings in this research add to a better understanding of tablet behaviour during disintegration due to variation in the formulation and processing conditions. This could lead to more knowledge-based approach to the innovation of future tablet formulations.
Supervisor: Salman, Agba D. Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available