Use this URL to cite or link to this record in EThOS: https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.755129
Title: Evaluation of CD8+ T-cell numbers and repertoires
Author: Ferrarini, Marco
ISNI:       0000 0004 7428 1271
Awarding Body: University of Leeds
Current Institution: University of Leeds
Date of Award: 2018
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Abstract:
This thesis tackles the problem of T-cell receptor (TCR) diversity, from two different points of view. On one hand, the observed TCR diversity is studied from a mathematical perspective, concentrating on the probability of a sample to reproduce a certain percentage of the total TCR diversity. On the other hand, biological samples are considered, focusing on statistical analysis of the observed VDJ gene segments. To conclude, a stochastic model is developed to explore the population dynamics of a simulated TCR repertoire. Computer simulations complete this multidisciplinary approach, helping verifying the different mathematical theories behind the stochastic models.
Supervisor: Lythe, Grant ; Molina-Paris, Carmen Sponsor: EU (Marie Curie Actions)
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID: uk.bl.ethos.755129  DOI: Not available
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