Use this URL to cite or link to this record in EThOS:
Title: Neural representations of active whisking in the cerebellum
Author: Chen, Susu
ISNI:       0000 0004 7427 6587
Awarding Body: Imperial College London
Current Institution: Imperial College London
Date of Award: 2016
Availability of Full Text:
Access from EThOS:
Access from Institution:
Active whisking is an important model sensorimotor behavior, but the function of the cerebellum in the rodent whisker system is unknown. I have made patch clamp recordings from Purkinje cells, granule cells and interneurons in vivo to identify whether and how cerebellar activity encodes kinematic features of whisking including the phase and set point. I show that Purkinje cell spiking activity changes strongly during whisking bouts. On average, the changes in simple spike rate coincide with or slightly precede movement, indicating that the synaptic drive responsible for these changes is predominantly of efferent (motor) rather than re-afferent (sensory) origin. Remarkably, on-going changes in simple spike rate provide an accurate linear read-out of whisker set point. Thus, despite receiving several hundred thousand discrete synaptic inputs across a non-linear dendritic tree, Purkinje cells integrate parallel fiber and interneuron input to generate precise information about whisking kinematics via linear changes in firing rate. In addition, I demonstrate that evidence is consistent in both granule cells and interneurons activity within the circuit, providing a linear encoding regime of whisker set point.
Supervisor: Chadderton, Paul ; Augustine, George Sponsor: Medical Research Council ; National University of Singapore
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral