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Title: Characterising a role for acetyl-coenzyme A synthetase 2 in the regulation of autophagy
Author: Azad, Arsalan Afzal
ISNI:       0000 0004 7426 4105
Awarding Body: University of Cambridge
Current Institution: University of Cambridge
Date of Award: 2018
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The important role of the central intermediary metabolite acetyl-coenzyme A (AcCoA)for several anabolic and catabolic pathways is well characterised. However, the role of AcCoA as the only known donor of acetyl groups for protein acetylation in regulation of enzyme activities, protein complex stability as well as epigenetic status off chromatin, is only recently emerging. Among multiple other pathways, the autophagy pathway has now been shown to be directly regulated by protein acetylation and deacetylation. Therefore, it was reasoned that the availability of AcCoA, via the modulation of AcCoA generating enzymes, may regulate autophagy. This study has focussed on the role of the acetate-mediated route to nuclear-cytosolic AcCoA synthesis, catalysed by AcCoA synthetase 2 (ACSS2), in the regulation of autophagy.
Supervisor: Wakelam, Michael Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
Keywords: ACSS2 ; autophagy ; acetyl-CoA ; acetylation ; post translational modifications ; epigenetics ; ACLY ; lipid synthesis